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¡¾Major Papers of the Laboratory¡¿
?YAP/TAZ interacts with RBM39 to confer resistance against indisulam. Ando T (corresponding author), Okamoto K, Ueda Y, Kataoka N, Shintani T, Yanamoto S, Miyauchi M, Kajiya M. Oncogenesis, 13(1):25, 2024
?AXL activates YAP through the EGFR¨CLATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma, Okamoto K, Ando T (corresponding author), Izumi H, Kobayashi SS, Shintani T, Gutkind JS, Yanamoto S, Miyauchi M, Kajiya M. Oncogene, 42:2869-2877, 2023
?EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1. Ando T, Arang N, Wang Z, Costea DE, Feng X, Goto Y, Izumi H, Gilardi M, Ando K, Gutkind JS. Communications Biology, 4:1237, 2021

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Education
In the School of Dentistry, we are responsible for teaching Oral Pathology and Oral Pathology Practice. Our curriculum covers the fundamental principles of pathogenesis and histopathological diagnosis for a range of conditions, including developmental abnormalities, inflammatory diseases, tumors, and cysts. In clinical practice, we guide students through actual case studies to demonstrate the critical role of oral pathology in determining treatment strategies and predicting patient prognosis.

Graduate School
For our graduate students, our program combines practical, hands-on training in daily pathological diagnosis (histopathology and cytopathology) with cutting-edge research guidance. This dual approach is designed to foster a research-oriented mindset and an international perspective, nurturing the next generation of oral pathologists and researchers. Ultimately, we provide comprehensive career path support for students aiming to become certified Oral Pathology specialists.

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Our lab conducts comprehensive research from elucidating the pathological mechanisms of diseases in the oral and maxillofacial regions, such as oral cancer and periodontitis, to developing novel diagnostic and therapeutic methods. We specifically focus on the relationship between genetic abnormalities and the Hippo-YAP/TAZ pathway in oral cancer, as well as the link between periodontitis and systemic diseases like liver disease, premature birth, and cardiovascular diseases.
We are advancing molecular pathology research using actual patient samples and looking ahead to the next generation of digital oral pathology, including the establishment of a biobank and the development of AI-driven image diagnostic systems. We also maintain active collaborations with institutions like the University of California, San Diego and Taipei Medical University in Taiwan.

Research Focus Areas
1. Elucidating the mechanisms of oral cancer development and progression (the link between genetic alterations and the Hippo-YAP/TAZ pathway).
2. Uncovering the mechanisms of drug resistance in oral cancer.
3. Investigating the immune evasion and microenvironment of oral cancer.
4. Clarifying the pathogenesis of salivary gland tumors and odontogenic tumors.
5. Explaining the link between periodontitis and systemic diseases (liver disease, premature birth, and cardiovascular diseases).
6. Developing novel diagnostics and therapeutics based on the discovered pathological mechanisms.
7. Developing next-generation diagnostic methods (molecular pathology and AI-powered image diagnosis).