麻豆AV

研究成果 2009-2018

2018

水沼正树、益村晃司、金井宗良

长寿変异株厂厂骋1変异株の特徴からみる酵母寿命の関连因子

日本醸造协会誌、印刷中.

 

水沼正树

栄养?代谢センシング経路による寿命制御机构

生化学(日本生化学会)、90巻、3号、印刷中.

 

中村 諒、中野久美子、田村博康、水沼正树、伏木 亨、平田 大

料理とともに味わう日本酒のおいしさの评価(新たな试み)

日本醸造协会誌、第113巻、5号、印刷中.

2017

K. Kume, H. Cantwell, F.R. Neumann, A.W. Jones, A.P. Snijders, and P. Nurse

A systematic genomic screen implicates nucleocytoplasmic transport and membrane growth in nucelar size control.

 

M. Kanai, M. Mizunuma, T. Fujii, and H. Iefuji

A genetic method to enhance the accumulation of S-adenosylmethionine in yeast.

 

K. Kume, T. Hashimoto, M. Suzuki, M. Mizunuma, T. Toda, and D. Hirata

Identification of three signaling molecules required for calcineurin-dependent monopolar growth induced by the DNA replication checkpoint in fission yeast.

 

M. Kanai, T. Kawata, Y. Yoshida, Y. Kita, T. Ogawa, M. Mizunuma, D. Watanabe, H. Shimoi, A. Mizuno, O. Yamada, T. Fujii, and H. Iefuji

Sake yeast YHR032W/ERC1 haplotype contributes to high S-adenosylmethionine accumulation in sake yeast strains.

 

R. Nakamura, K. Nakano, H. Tamura, M. Mizunuma, R. Fushiki, and D. Hirata

Evaluation of the comprehensive palatability of Japanese sake paired with dishes by multiple regression analysis based on subdomains.

 

M. Yukawa, T. Kawakami, M. Okazaki, K. Kume, N.H. Tang, and T. Toda

A microtubule polymerase cooperates with the kinesin-6 motor and a microtubule cross-linker to promote bipolar spindle assembly in the absence of kinesin-5 and kinesin-14 in fission yeast.

小川貴史、水沼正树

メチオニン代谢が键となる酵母の长寿の仕组み

化学と生物(日本农芸化学会)、55巻、8号、526-528(2017).

 

小川貴裕、小寺幸広、水沼正树

モデル生物线虫C. elegansを用いた熟成ニンニクの机能解析

化学と生物(日本农芸化学会)、55巻、6号、372-374(2017).

2016

T. Ogawa, R. Tsubakiyama, M. Kanai, T. Koyama, T. Fujii, H. Iefuji, T. Soga, K. Kume, T. Miyakawa, D. Hirata, and M. Mizunuma

Stimukating S-adenosyl-L-methionine synthesis extends lifespan via activation of AMPK.

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T. Ogawa, Y. Kodera, D. Hirata, TK Blackwell, and M. Mizunuma

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf.

 

I. Nunez, M. R. Pino, D. J. Wiley, M. E. Das, C. Chen, T. Goshima, K. Kume, D. Hirata, T. Toda, and F. Verde

Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

 

T. Goshima, R. Nakamura, K. Kume, H. Okada, E. Ichikawa, H. Tamura, H. Hasuda, M. Inahashi, N. Okazaki, T. Akao, H. Shimoi, M. Mizunuma, Y. Ohya, and D. Hirata

Identification of a mutation causing a defective spindle assembly checkpoint in high ethyl caproate-producing sake yeast strain K1801.

 

K. Kume

Elutriation for cell cycle synchronization in fission yeast.

2015

T. Koyano, K. Barnouin, A. Snijders, K. Kume, D. Hirata, and T. Toda

Casein kinase 1γ acts as a molecular switch for cell polarization through phosphorylation of the polarity factor Tea1 in fission yeast.

 

K. Wan, H. Kawara, T. Yamamoto, K. Kume, Y. Yabuki, T.Goshima, K. Kitamura, M. Ueno, M. Kanai, D. Hirata, K. Funato, K. Mizuta

The essential function of Rrs1 in ribosome biogenesis in conserved in budding and fission yeasts.

 

T. Koyano, M. Konishi, SG Martin, Y. Ohya, D. Hirata, T. Toda, and K. Kume

Casein Kinase 1γ ensures monopolar growth polarity under incomplete DNA replication downstream of Cds1 and Calcineurin in fission yeast.

 

H. Tamura, H. Okada, K. Kume, T. Koyano, T. Goshima, R. Nakamura, T. Akao, H. Shimoi, M. Mizunuma, Y. Ohya and D. Hirata

Isolation of a spontaneous cerulenin-resistant sake yeast with both high ethyl caproate-producing ability and normal checkpoint integrity.

 

K. Kume, T. Koyano, J. Takata, K. Wakabayashi, M. Mizunuma, T. Miyakawa and D. Hirata

Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application for a positive screening for drugs inhibiting calcineurin.

 

田村博康、栗林 喬、久米一規、五島徹也、中村 諒、渡邊健一、赤尾 健、下飯 仁、水沼正树、平田 大

カプロン酸エチル高生产性清酒酵母の迅速识别法

日本醸造协会誌、第110巻、12号、820-826.

2014

M. Mizunuma, E. Neumann-Haefelin, N. Moroz, Y. LI and T. K. Blackwell

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity.

 

Y. Anzawa, K. Satoh, Y. Satoh, S. Ohno, T. Watanabe, K. Katsumata, K. Kume, K. Watanabe, M. Mizunuma, and D. Hirata

Late-maturing cooking rice Sensyuraku has excellent properties, equivalent to sake rice, for high-quality sake brewing.

2013

M. Mizunuma, R. Tsubakiyama, T. Ogawa, A. Shitamukai, Y. Kobayashi, T. Inai, K. Kume, and D. Hirata

Ras/cAMP-dependent protein kinase (PKA) regulates multiple aspects of cellular events by phosphorylating the Whi3 cell cycle regulator in budding yeast.

 

K. Kume, S. Kubota, T. Koyano, M. Kanai, M. Mizunuma, T. Toda, and D. Hirata

Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR).

 

M. Mizunuma, T. Ogawa, T. Koyama, A. Shitamukai, R. Tsubakiyama, T. Komaruyama, T. Yamaguchi, K. Kume, and D. Hirata

Evidence of antagonistic regulation of restart from G1 delay in response to osmotic stress by the Hog1 and Whi3 in budding yeast.

 

Y. Anzawa, Y. Nabekura, K. Satoh, Y. Satoh, S. Ohno, T. Watababe, M. Kaneoke, K. Kume, M. Mizunuma, K. Watanabe, K. Katsumata, and D. Hirata

Polishing properties of sake rice Koshitanrei for high-quality sake brewing.

 

T. Kuribayashi, H. Tamura, K. Sato, Y. Nabekura, T. Aoki, Y. Anzawa, K. Katsumata, S. Ohdaira, S. Yamashita, K. Kume, M. Kaneoke, K. Watanabe, and D. Hirata

Isolation of a non-urea-producing sake yeast strain carrying a discriminable molecular marker.

 

N. Aburai, J. Yoshida, M. Kobayashi, M. Mizunuma, M. Ohnishi and K. Kimura

Pisferidiol restores the growth of a mutant yeast suffering from hyperactivated Ca2+ signaling through calcineurin inhibition.

2012

S. Robida-Stubbs, K. Glover-Cutter, D. W. Lamming, M. Mizunuma, S. D. Narasimham, D. Neumann-Hawfelin, D. M. Sabatini, and T. K. Blackwell

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

 

T. Kuribayashi, M. Kaneoke, D. Hirata and K. Watanabe

Analysis of free fatty acids in sake by an enzymatic method and its application for estimating ethyl caproate and selecting yeast with high productivity of the ester.

 

S. Ohnuki, T. Kobayashi, H. Ogawa, I. Kozone J. Ueda, M. Takagi, K. Shin-ya, D. Hirata, S. Nogami and Y. Ohya

Analysis of the biological activity of a novel 24-membered macrolide JBIR-19 in Saccharomyces cerevisiae by the morphological imaging program CalMorph.

2011

R. Tsubakiyama, M. Mizunuma, A. Gemgyo, J. Yamamoto, K. Kume, T. Miyakawa, and D. Hirata

Implication of Ca2+ in the regulation of replicative life span of budding yeast.

 

K. Kume, T. Koyano, M. Kanai, T. Toda, and D. Hirata

Calcineurin ensures a link between the DNA replication checkpoint and microtubule-dependent polarized growth.

 

C. Ikebe, M. Konishi, D. Hirata, T. Matsusaka, and T. Toda

Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.

 

S. Kawamoto, M. Kaneoke, K. Ohkouchi, Y. Amano, Y. Takaoka, K. Kume, T. Aki, S. Yamashita, K. Watanabe, M. Kadowaki, D. Hirata, and K. Ono

Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.

2010

T. Goshima, K. Kume, T. Koyano, Y. Ohya, T. Toda, and D. Hirata

Fission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.

 

S. Ray, K. Kume, S. Gupta, W. Ge, M. Balasubramanian, D. Hirata, and D. McCollum

The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

 

T. Koyano, K. Kume, M. Konishi, T. Toda, and D. Hirata

Search for kinases related to transition of growth polarity in fission yeast.

 

S. Attrapadung, J. Yoshida, K. Kimura, M. Mizunuma, T. Miyakawa, and B.W. Thanomsub

Identification of ricinoileic acid as an inhibitor of Ca2+ signal-mediated cell-cycle regulation in budding yeast.

2009

A. Ano, D. Suehiro, K. Cha-aim, K. Aritomi, P. Phonimdaeng, N. Nontasa, H. Hoshida, M. Mizunuma, T. Miyakawa, and R. Akada

Combinatorial gene overexpression and recessive mutant gene introduction in sake yeast.


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