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Molecular Pathology

Prof. MII Shinji

¡¾Research Keyword¡¿
Tumor Pathology, Stromal Pathology, Cancer-Associated Fibroblasts, Comprehensive Genomic and Transcriptomic Analysis, Gastrointestinal Cancer, Development of Novel Diagnostics and Therapeutics, Cancer Stem Cells, Genome Editing

¡¾Recent highlights¡¿
Pathology is an integrated medical science that investigates the causes and mechanisms of diseases.
In the Molecular Pathology Laboratory, we perform advanced, exploratory, and applied pathological research based on disease mechanisms across various organs. Additionally, we practice pathological diagnosis and are committed to training future specialized pathologists. Our research has contributed to identifying novel cancer stem cell markers as potential diagnostic and therapeutic targets.
Recently, we have been focusing not only on genome and transcriptome analyses but also on leveraging traditional immunohistochemical methods to study the cancer-stroma interface. Notably, we have reported that CD109, identified as a cancer-promoting factor highly expressed in squamous cell carcinoma, is involved in brain tumors, lung adenocarcinoma, pancreatic cancer, and osteosarcoma. For instance, CD109 has been shown to promote stromal invasion in lung cancer. Based on these findings, we continue to research tumor progression mechanisms and their impact on maintaining biological homeostasis.

¡¾Major Papers of the Laboratory¡¿
?Kojima Y, Mii S, Hayashi S, Hirose H, Ishikawa M, Akiyama M, Enomoto A, Shimamura T. Single-cell colocalization analysis using a deep generative model. Cell Syst. Cell Systems. 15:180-192, 2024.
?Taki T, Shiraki Y, Enomoto A, Weng L, Chen C, Asai N, Murakumo Y, Yokoi K, Takahashi M, Mii S. CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-¦Â signaling. Cancer Sci. Cancer Science. 111:4616-4628, 2020.
?Mii S, Enomoto A, Shiraki Y, Taki T, Murakumo Y, Takahashi M. CD109: a multifunctional GPI-anchored protein with key roles in tumor progression and physiological homeostasis. Pathol Int. Pathology International. 69:249-259, 2019.
?Shiraki Y, Mii S, Enomoto A, Momota H, Han YP, Kato T, Ushida K, Kato A, Asai N, Murakumo Y, Aoki K, Suzuki H, Ohka F, Wakabayashi T, Todo T, Ogawa S, Natsume A, Takahashi M. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma. J Pathol. Journal of Pathology. 243:468-480, 2017.
?Mii S, Murakumo Y, Asai N, Jijiwa M, Hagiwara S, Kato T, Asai M, Enomoto A, Ushida K, Sobue S, Ichihara M, Takahashi M. Epidermal hyperplasia and appendage abnormalities in mice lacking CD109. Am J Pathol. American Journal of Pathology. 181:1180-1189, 2012.

¡¾·¡»å³Ü³¦²¹³Ù¾±´Ç²Ô¡¿
We provide education on the foundational knowledge necessary to understand the concepts of diseases, their mechanisms, and the relationships between diagnosis and treatment. This includes learning to identify pathological and morphological changes and recognizing abnormalities at the genetic and molecular levels. At a more advanced level, we offer instruction in molecular pathology and tumor pathology. Through molecular pathology experiments on various malignant tumors, including gastrointestinal cancers, students can acquire skills in experimental techniques, data analysis, and scientific writing.

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  1. Functional and morphological analysis of tumor progression
  2. Molecular pathological study on the role of "cancer stem cells"
  3. Histopathological analysis of novel cancer-related molecules
  4. Analysis of the cancer-stroma interface focusing on cancer-associated fibroblasts
  5. Stromal pathological study of homeostasis maintenance


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School of Medicine

1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, Japan 734-8553
TEL: +81-82-257-1705