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¡¾Major Papers of the Laboratory¡¿
?Hamamoto T, Sato Y, Yumii K, Chikuie N, Taruya T, Horibe Y, Ishino T, Ueda T, Takeno S, Yoshimura K. Evaluation of the Safety of Percutaneous Sensory Nerve Stimulation in Patients with Head and Neck Cancer Receiving Chemoradiotherapy. J Pers Med. 2023 Jul 12;13(7):1129. doi: 10.3390/jpm13071129. PMID: 37511742
?Yumii K, Ueda T, Kawahara D, Chikuie N, Taruya T, Hamamoto T, Takeno S. Artificial intelligence-based diagnosis of the depth of laryngopharyngeal cancer. Auris Nasus Larynx. 2023 Oct 12:S0385-8146(23)00173-6. doi: 10.1016/j.anl.2023.09.001.
?Ishino T, Oda T, Kawasumi T, Takemoto K, Nishida M, Horibe Y, Chikuie N, Taruya T, Hamamoto T, Ueda T, Takeno S. Severe Type 2 Inflammation Leads to High Platelet-Activating-Factor-Associated Pathology in Chronic Rhinosinusitis with Nasal Polyps-A Hierarchical Cluster Analysis Using Bulk RNA Barcoding and Sequencing. Int J Mol Sci. 2024 Feb 9;25(4):2113. doi: 10.3390/ijms25042113. PMID: 38396790
?Hirokane S, Kawasumi T, Takeno S, Okamoto Y, Miyamoto S, Fujita R, Ishikawa C, Oda T, Horibe Y, Ishino T, et al. Impaired Coordination of the Ciliary Movement in Patients with Chronic Rhinosinusitis with Nasal Polyps: The Role of Decreased Planar Cell Polarity Protein Expression. Immuno. 2024; 4(3):247-265.
?Ishino T, Nakagawa K, Higashikawa F, Hirokane S, Fujita R, Ishikawa C, Kawasumi T, Takemoto K, Oda T, Nishida M, Horibe Y, Chikuie N, Taruya T, Hamamoto T, Ueda T, Yuge L, Takeno S. Intelligibility Sound Therapy Enhances the Ability of Speech-in-Noise Perception and Pre-Perceptual Neurophysiological Response. Biology (Basel). 2024 Dec 6;13(12):1021. doi: 10.3390/biology13121021. PMID: 39765688

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Otorhinolaryngology covers all human organs above neck except the brain and eyes. We deal with disorders of sensory organs associated with hearing, balance, smell and gustation, facial nerve function, deglutition and phonation disorders, salivary gland diseases and head and neck tumor, i.e. in addition to all diseases about ear, nose, pharynx and larynx. We provide lecture about pathophysiology, diagnosis and therapy of these diseases so as to make you understand them comprehensively. Our learning skills about basic knowledge and practice of otorhinolaryngology refers its associated fields. Lectures are given by staffs who major specific disease groups according to the syllabus. Moreover, professors from other universities whose knowledge and experience are wide and deep take charge of some diseases.

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Allergology and Rhinology
¡¡Research on the pathogenesis of allergic and eosinophilic inflammation in the upper airway;
¡¡Molecular biological study of eosinophilic rhinosinusitis
¡¡Research on the pathogenesis of allergic rhinitis and development of a new therapy
¡¡Research on the functional role of nitric oxide in the upper airway
 Hearing and Audiology
¡¡Clinical research on cochlear implant
¡¡Molecular and genetical analysis of sensory neural hearing loss
¡¡Introduction of trans ear endoscopic canal surgery
 Head and Neck tumor
¡¡Organizing member of Japan Clinical Oncology Group(JCOG£©, Head and Neck cancer division
¡¡Introduction of Video-assisted neck surgery
¡¡Research on the pathogenesis of head and neck cancer and development of methods for outcome prediction
¡¡Development of accurate diagnosis method for head and neck cancer
¡¡Biomarker study in the patients treated with anti-PD 1 antibody for recurrent or metastatic head and neck squamous cell carcinoma (cooperative research with the Birmingham University)